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Causes of Impotence and/or Erectile Dysfunction


Impotence is defined as the inability to achieve or maintain an erection sufficient for mutually satisfying intercourse. Recently the term Erectile Dysfunction has been interchanged with Impotence. Erectile Dysfunction is defined as the following:

The inability to achieve penile erection or to maintain an erection until ejaculation. Also called impotence. The incidence of Impotence or Erectile Dysfunction often correlates with a man's age, some 67% of men by the age of 70 years old have some difficulties achieving an erection.

Stress also as a significant impact on man's ability to perform. Over the last decade we have seen a considerable rise in the incidence of impotence in men in their mid thirties and even younger. Stress has been noted as an important cause of impotence in this age group.

 Impotence impacts more than a man's sexual activity. The emotions and uncertainties that coincide with this condition often have a significant effect on a man's self-esteem, as well as, his relationship with his partner. Although the incidence of Impotence increases with age, it is not an inevitable result of aging. Impotence is a secondary condition linked to many medical conditions.

Fortunately, there are now very effective methods to treat impotence. For a detailed description of the most recommended impotence treatment options by Urologist (doctors that specialize in this type of medicine) please visit the following webpage:

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The first step in treating Impotence is that the individual understands the psychology, physiology and anatomy responsible for the ability to achieve and maintain an erection. If we can comprehend these events than we can better understand the factors that are responsible for Impotence and address the questions concerning treatment.

Normal Erectile Function

For something that appears so natural, an erection is a rather complicated process involving the coordination of the psychological, neurological and cardiovascular systems. The penis becomes erect following a series of events. First, the nerves are stimulated, a sensation known as arousal. No matter what the nature of the stimulus, visual, mental or physical the brain coordinates the following series of events:

  • Nerve impulses transverse the length of the spinal cord to the pudendal nerve and on to the penis. Smooth muscle within the walls of the penile arteries respond by relaxing. Subsequently, the penile arteries dilate allowing up to eight times more blood to flow into the corpora cavernosum, (two parallel cylinders that transverse the length of the penis).

  • The cavernosum become engorged with blood expanding and lengthening the penis. The expanding tissue then exerts a positive pressure compressing the veins that normally empty the blood from the penis, maintaining the blood in the penile tissue. When ejaculation occurs or when arousal is discontinued the penis returns to its non-erect state.



Causes of Impotence

Historically, when an individual consulted his physician concerning Impotence he was usually informed there were no known physiological answers concerning his condition. Today, a generation of research has resulted in significant advances in both the diagnosis and treatment of Impotence. Physicians now understand that approximately 85% of Impotence is attributable to physical/organic conditions while only 15% is due to psychological or mixed origin (both psychological and organic). Some important causes of physiological Impotence are as follows:

Vascular Disease

Vascular Disease is the leading cause of Impotence. Vascular disorders include arteriosclerosis (hardening of the arteries), hypertension, hyper-cholestremia and other conditions which interfere with the blood flow to the penis. Additionally, "venous leakage", a condition occurring when the penile veins are unable to constrict efficiently during an erection, also contributes to poor erections. When these veins "leak", blood escapes to the periphery resulting in a poor erection.


Diabetes is another common cause of Impotence. Approximately 50% of men with insulin dependent diabetes experience some degree of ED after 55 years old. Diabetes results in poor circulation and/or peripheral neuropathy. When the nerves are involved, sexual stimuli are not transmitted appropriately to or from the brain and Impotence develops.


Neurological diseases such as multiple sclerosis, Parkinson's disease, spinal cord injuries and long term effects of diabetes can also result in the disruption of the normal sequence of events necessary for an erection to occur.


Endocrine System



Deficiencies in the Endocrine System are another source of Erectile Dysfunction. Low levels of testosterone or thyroid hormone can interfere with the stimulation process necessary in the erection sequence. Excessive production of prolactin by the pituitary gland may contribute to decreased levels of testosterone resulting in a lack of desire. Diabetes once again enters the scenario as it is classified as an endocrine disorder.


Prescription medications often cause Impotence as a side effect. Some two hundred known medications fall into this category including:

Antihypertensives medications specifically:

  1. beta-blockers e.g. Atenolol, Propanolol and Tenorium.
    Diuretics medications e.g. HydroDiuril and Lasix.
  2. Ace Inhibitors/Calcium Channel Blockers medications e.g. Vasotec®, Lotension®,
  3. Cardizem® and Norvasc® periodically cause Erectile Dysfunction, however, they are generally represent an excellent alternative medication for individuals with drug induced Impotence.

Antidepressant/Antipsychotic medications -of almost any label can also result in Erectile Dysfunction e.g. Prozac®, Elavil®, Zoloft®, Thorazine® and Haldol®. Note: Many other medications in a variety of classes can periodically cause Impotence. If you take a prescription medication or an over-the-counter medication, regularly, please consult with your physician. However, never alter a dosage or discontinue a medication without the advice of your physician.

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Smoking and Impotence

Smoking as been linked to Impotence in numerous clinical studies.

The most common causes of the organic component in erectile dysfunction or impotence are vascular abnormalities associated with atherosclerosis and diabetes mellitus. Atherosclerosis causes 40% of cases of erectile dysfunction, and in cases of diabetes mellitus the prevalence of erectile dysfunction is 50%. Smoking is significantly associated with the development of both atherosclerosis and diabetes mellitus.

The Epidemiology and Pathophysiology of Impotence.
The Journal of Urology 1999 Jan; 161(1):5-11


After smoking two cigarettes, the diameter of the internal pudendal artery narrows and the penile arteries almost completely close. This evidence suggests that smoking can cause an acute vasospastic constriction of the arteries in the penis. These observations are supported by physiological evidence that nicotine causes acute peripheral vasoconstriction. Acute Vasospasm of Penile Arteries in Response to Cigarette Smoking. Urology 1990; 36(1):99-100

 

Aside from impotence, smoking as also been linked to the following negative effect concerning male sexual health:

  • Reduced volume of ejaculation
  • Lowered sperm count
  • Abnormal sperm shape
  • Impaired sperm motility

LH-RH Analogs/Antiandrogen medications and Impotence are medications are used in the treatment of prostate cancer. They function by decreasing the production of testosterone in the testes and adrenal glands, which decrease in testosterone often results in Erectile Dysfunction.


Chemotherapy/Radiation and Impotence therapy is also a significant contributors to Impotence. These drugs/treatments are used in the treatment of cancer.


Substance Abuse and Impotence can also negatively effect male potency. The chronic use of cocaine, marijuana, alcohol, steroids etc. often results in Erectile Dysfunction, as well as a decrease in desire. Excessive tobacco use can also attribute to Impotence by accentuating the effects of other risk factor such as vascular disease or hypertension.


Radical Pelvic Surgery and Impotence also result in Erectile Dysfunction. Surgical procedures involving the prostate gland, bladder or colon may interfere with the nerves involved in the erectile response. Radiation therapy for cancer may also effect the erectile process.


Psychological Impotence is usually diagnosed when no physical causes can be defined. Pure psychological Impotence usually occurs suddenly without warning as opposed to physical ED that may gradually develop over the years.

Some common causes of psychological Impotence are as follows:

  • Performance anxiety is one of the most common causes of psychological Impotence. When a man feels pressured to achieve or maintain an erection, he will commonly become anxious and nervous when in a sexually demanding situation. Stress increases the body's production of catecholamines such as adrenaline and nor- adrenaline, which act as erection inhibitors. The release of these inhibitors further contributes to failure resulting in more anxiety. Therefore, the cycle begins, increased stress resulting in increased catecholomines that further inhibits the erectile process.
  • Depression is another cause of psychogenic Impotence. Unfortunately, many of the popular antidepressant medications (for a list see prescription medications in the next section) have side effects which include erectile failure.
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Anatomical Deviation of the Penis and Impotence


Anatomical Deviation of the Penis, known as Peyronie's Disease, may also cause impotence. This condition usually develops from an inflammatory process and results in fibrous scaring of the penis. The cause of this process is not yet understood; however, when an erection does occur, there is a bending of the penis secondary to the scar tissue. This curvature may interfere with erectile capacity and/or ejaculation.



 

Impotence Treatment Options

Until recently, individuals who sought medical treatment for Impotence were told "It's all in your head". Physicians labeled these individuals with a psychological disorder and they were referred to counseling. Today, there are many treatment options available. The treatment option you choose should be specific and responsive to your needs and expectations as well as your partners. 

Medication Information -currently there are several oral medications for the treatment of impotence including Viagra, Cialis, Levitra and Uprima.

Simply click on the any of the following popular impotence treatment medications for detailed information:

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Mechanism of Action of the Various Impotence Medications:

The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Some Medication Information enhance the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum.

Some impotence medications stimulate dopamine receptors in the hypothalamus and mid brain regions. Subsequently, once sexual stimulation as occurred an excitatory signal is transmitted via the spinal cord to stimulate parasympathetic activity in the pelvic region that results in smooth muscle relaxation in the walls of the arteries supplying the penis. The relaxation of walls of these arteries allows the arteries to expand so more blood can flow to the region, hence, improved erections.

Other impotence medications exert their action by effecting two enzymes, Cyclic guanosine monophosphate (cGMP) and phosphodiesterase type 5 (PDE5) that play important roles in erectile function. Sexual stimulation triggers the local release of nitric oxide (NO) from nerves and endothelial cells in the penis. NO stimulates an enzyme that catalyzes formation of cGMP from the nucleotide guanosine 5-triphospate (GTP) in the penile blood vessels and corpus cavernosum walls.

The cGMP causes vasodilation of arteries, allowing the influx of blood into the corpus cavernosum. Increased blood flow into the penis causes the erectile tissue to expand. When the erectile tissue has expanded sufficiently, the veins draining the corpus cavernosum become compressed. This decreases the outflow of blood from the penis, and the blood remains in the corpus cavernosum to keep the penis erect.

The enzyme PDE5 eventually causes degradation of the cGMP, and the erection ends.

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Additional Impotence Treatment Options


Herbal Approaches for the treatment of impotence have become very popular as an initial treatment for Impotence. Herbal supplements for the treatment erectile dysfunction should contain a combination of the following ingredients: Yohimbe (bark), Maca (root), Horny Goat Weed (leaf), Saw Palmetto (berry), Schizandra (berry), Guarana (seed) Tribulus Terrestris (aerial part), Ashwagandha (root), Asparagus Racemosus (aerial part), Ginger (root) Cayenne Pepper (berry), L Tyrosine, and L Histidine. Physicians' Select Male Enhancement capsules provide the most complete ingredients for the herbal treatment of erectile dysfunction.


Penile Injection Therapy: treatment of impotence uses a hypodermic needle to inject medication that is a mixture of papaverine, phentolamine and prostoglandin into the side of the penis. The medication relaxes the smooth muscle tissue of the penis allowing for an erection. These injections can be painful, result in scare tissue formation at the injection site and cause priapism, the prolonged and painful engorgement of the penis).


 

Urethral Inserts: treatment of impotence consists of a disposable applicator, small enough to fit into the urethra. The applicator is inserted into the urethra approximately one inch and the prostaglandin E-1 medication is released. As a result, an erection occurs lasting 30-60 minutes. Patient acceptance is still an issue secondary to expense and the low success rate as compared to other treatments for Impotence.


Hormonal Therapy: Impotence treatment is used to treat the small percentage of individuals who have abnormally low levels of testosterone. During the initial consultation, a physician will likely order LH and Prolactin hormone test to exclude other causes of low testosterone levels. If appropriate, testosterone is available in a transdermal adhesive patch.


Vascular Surgery: Impotence treatment may involve both the arterial and venous systems. Venous ligation has been reported to be effective in patients with venous leakage. However, it is often difficult to diagnose individuals with this condition with the current testing capabilities; therefore, it is difficult to predict their outcome prior to surgery. Arterial re-vasculation procedures are limited to congenital or traumatic vascular abnormalities. Similar to venous testing, complete standardization diagnostic testing has not been established, so difficulties persists in predicting surgical results.


Penile Implants: Impotence treatment requires surgical insertion of a prosthetic device. Three forms of penile prosthesis are currently available flexible, malleable and inflatable. Flexible or Malleable rods consist of two semi-rigid, flexible rods that make the penis firm enough for intercourse. There are also inflatable prosthetic devices that produce a more natural erection. When an erection is desired the pump (located in the scrotum) is squeezed, this in turn inflates a cylinder, which creates an erection.

Following intercourse, the pump is released and the penis returns too normal. These devices have been associated with postoperative infections, mechanical failure, silicon particle shedding and the risk of the initial surgery.


Psychotherapy and/or Behavioral Therapy: Impotence treatment have been found to be beneficial in treating Impotence. Although the majority of causes of impotence are physical, there are quite frequently underlying psychosocial factors involved as well. Psychotherapy and/or behavioral therapy may be helpful in individuals whom no organic cause for Impotence has been detected. Therapy often focuses on complications surrounding performance anxiety, dysfunctional relationships, loss of a partner, psychotic disorders, substance abuse, etc.

Final Notes, Impotence Treatment Options

In conclusion, more doctors recommend either Viagra or Cialis for their patients who need an impotence treatment


Uprima one of the fastest acting erection enhancement impotence treatment drugs.While Viagra remains the most prescribed impotence treatment medication, Cialis represents the longest lasting impotence treatment medication, the erection enhancement benefits of Cialis can last up to thirty-six hours following a single dose.

We now offer detailed information concerning these two impotence treatment medications Viagra and, Cialis.

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